Research

During the last 10 years, the research activity has been focused on the development of biochips and immunosensors dedicated to biomedical applications and pesticide detection. 

We immobilize various types of molecules (e.g. proteins) on arrays, analyse images and quantify the signal. We also characterize the new analysis methods to identify their performances. At the same time, we perform the biofunctionalization  of the micro and nanoparticles of various materials: polymers, paramagnetic or gold particles.

Research Projects. 

The Company is permanently investing in research and development and is involved in national research – development projects under partnerships with research institutes, universities and other companies, with a special focus on the development of IVD products. 

DDS Diagnostic is certified for the research-development activity by ANCS (National Authority for Scientific Research) (Decision 9847/22.04.2010).

For over 15 years, our research-development activity covers the field of serum protein electrophoresis, immuno-reactions techniques: ELISA, CLIA, immunochromatography, biochips and immunosensors. Our main products are: serum protein agarose gel electrophoresis kits, ELISA kits, CLIA kits, rapid immunoagglutination and immunochromatography tests.

The development of these methods and of the specific diagnosis kits, represent the applied research sector of our company. Some methods/techniques were developed some 50 years ago yet they are still being largely used in laboratories all over the world and are permanently improved to increased performances. Gradually, however, these techniques will be replaced by more advanced technologies, which are currently, at global level, in a research stage.

The biochips as well as the immunosensors are manufactured through advanced state of the art technologies, based on innovative ideas of DDS Diagnostic’s specialists as well as to the access to the next-generation equipment, thanks to our collaborations with prestigious research institutes from Romania. We are specialised in the biofunctionalization of gold or nitrocellulose microarrays to quantifying analytes from human biological samples: antigens or antibodies.

Our partners

Another research line is the biofunctionalization of the micro or nanoparticles of various materials: polymers, paramagnetic or gold particles. These are used in the detection of certain antigen or antibody, biomarkers from biological human samples or in the selective marking of certain cells such as subpopulations of T lymphocytes.

To confirm and assess the success of the biofunctionalization process, during, as well as upon the completion thereof, we use advanced characterization methods: RAMAN spectroscopy, infrared Fourier transform spectroscopy with attenuated total reflectance – FTIR-ATR, atomic force microscopy – AFM, scanning electron microscopy – SEM, transmitted electron microscopy –TEM, spectrophotometry UV-VIS, electrochemical impedance spectroscopy. The collected data are processed, interpreted and correlated.

About the research activity

 

Total projects 2004 – 2019

15 projects

 

  • 2004-2020
    Partner
    MATNANTECH

    "Obtaining biogels for electrophoretic separation of serum proteins with applications in diagnosis and therapy"

  • 2014
    Partner
    Lab on Chip

    "Laboratory on a chip for the detection of tumor cell activity"

  • 2020-2021
    Partener
    Covid-19 IgM / IgG antibody kit

    "Increasing the diversity and quality of immunochromatographic diagnostic products, by introducing technological gamma irradiation and adding positive external controls"

    Product 2020 - COVID-19 IgM / IgG Antibody Kit with controls included, CE marking

  • 2020-2022 (CO)FRET & IMA

    Förster rapid resonance detection (FRET) prototype microbiosensor manufacturing technology for early diagnosis of acute myocardial infarction (AMI)


Research results

  • Patent: “Method for obtaining a selective template for the“ unlabeled ”electrochemical detection of adiponectin in human biological samples” published with No. 132771A0 published in the Official Bulletin of Industrial Property-OSIM Section No. 8 of 2018
  • "The process of electrochemical functionalization of interdigitated electrodes for the detection of CD4 + surface receptor antigen of T-CD4 + lymphocyte subpopulations", OSIM patent application no. A / 00572 / 08.08.2018.

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