Förster rapid resonance microbiosensor (FRET) prototype manufacturing technology for early diagnosis of acute myocardial infarction (AMI)

CardioFRET


Program PN III: Program 2-Increasing the competitiveness of the Romanian economy through research, development and innovation

Subprogram name: Subprogram 2.1 - Competitiveness through research, development and innovation
Project type: Transfer project to the economic operator
Project financed from the state budget and co-financed by DDS Diagnostic
Contract No. 37PTE / 2020
Period: 2020-2022
Coordinator: DDS DIAGNOSTIC S.R.L Bucharest
Project Director: Dr. Dana STAN

Scopul principal al proiectului

Development and development of prototypes of fluorescence detection microbiosensors based on Förster resonance energy transfer (FRET) for fast and sensitive detection of whole blood samples of 4 important cardiac markers in acute myocardial infarction (AMI) using an analyzer with fluorescence detection.

General objectives of the project

O1. Development, manufacture and testing of microbiosensors for the determination with high sensitivity of 4 important cardiac markers in the diagnosis of AMI: hFABP, CK-MB, myoglobin, troponin ITC complex;
O2. Connecting applied research and technological progress in Romania to the evolution and requirements of the national and international socio-economic environment;
O3. Development of partnerships between the research environment and the private environment;
O4. Stimulating the growth of private sector spending on research and development, both for their own activities and for collaboration with research organizations;
O5. Strengthening the innovation capacity of enterprises and consolidating their contribution to the creation of new products (microbiosensors for in vitro diagnostics) / technologies (microbiosensors manufacturing) with the potential for commercial exploitation on the domestic and international market;

Consortium

Coordinator: S.C. DDS Diagnostic S.R.L.
Project manager: Dr. Dana STAN
Partner: National Research and Development Institute for Microtechnology Bucharest (IMT)
Project manager: Dr. Carmen Marinela MIHAILESCU

Expected results:

The final microbiosensor box prototype will be made.
The clinical study will be performed in compliance with the ethical norms in force.
Technology validation and technology transfer to DDS will be performed.
The results will be disseminated through the organization of workshops, participation in specialized conferences and publication of articles in scientific journals.

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